Indian Journal of Plastic Surgery
An open access publication of Association of Plastic Surgeons of India
Users Online: 1158  
Home | Subscribe | Feedback | Login 
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed982    
    Printed11    
    Emailed0    
    PDF Downloaded68    
    Comments [Add]    

Recommend this journal

 

 ORIGINAL ARTICLE
Year : 2017  |  Volume : 50  |  Issue : 2  |  Page : 168--172

First two bilateral hand transplantations in India (Part 4): Immediate post-operative care, immunosuppression protocol and monitoring


1 Department of Plastic and Reconstructive Surgery; Department of Head and Neck Surgery; Department of Craniomaxillofacial Surgery; Amrita Institute of Medical Sciences, Kochi, Kerala, India
2 Department of Plastic and Reconstructive Surgery, Amrita Institute of Medical Sciences, Kochi, Kerala, India
3 Department of Nephrology, Amrita Institute of Medical Sciences, Kochi, Kerala, India
4 Department of Pathology, Amrita Institute of Medical Sciences, Kochi, Kerala, India
5 Department of Molecular Diagnostics, Amrita Institute of Medical Sciences, Kochi, Kerala, India

Correspondence Address:
Subramania Iyer
Department of Plastic and Reconstructive Surgery, Tower 1, 4th Floor, Amrita Institute of Medical Sciences, AIMS Ponekkara P. O., Kochi - 682 041, Kerala; Department of Head and Neck Surgery, Tower 1, 4th Floor, Amrita Institute of Medical Sciences, AIMS Ponekkara P. O., Kochi - 682 041, Kerala; Department of Craniomaxillofacial Surgery, Tower 1, 4th Floor, Amrita Institute of Medical Sciences, AIMS Ponekkara P. O., Kochi - 682 041, Kerala
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijps.IJPS_96_17

Rights and Permissions

Introduction: Being able to counter immune-mediated rejection has for decades been the single largest obstacle for the progress of vascular composite allotransplantation (VCA). The human immune system performs the key role of differentiating the 'self ' from the 'non-self '. This, although is quintessential to eliminate or resist infections, also resists the acceptance of an allograft which it promptly recognises as 'non-self'. Materials and Methods: Pre-operative evaluation of the recipient evaluation included immunological assessment in the form of panel reactive antibodies (PRA), human leucocyte antigen (HLA) typing, donor-specific antibody detection assays (DSA) and complement-dependent cytotoxicity assays (CDC). Induction immunosuppression was by thymoglobulin and the maintenance by the standard triple-drug therapy. Results: Both the recipients were managed by the standard triple drug therapy and have had only minor episodes of rejections thus far which have been managed appropriately. Discussion: Induction immunosuppression was by thymoglobulin and the maintenance by the standard triple-drug therapy. Various groups have tried various other formulations and regimes as well. Conclusion: A comprehensive plan has to be drawn up for immunological screening, selection and the post-operative immunosuppressant usage. The ultimate goal of these immunosuppression modalities is to achieve a state of donor-specific tolerance.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map  |  Home  |  Contact Us  |  Feedback  |  Copyright and Disclaimer
Online since 11th March '04
Published by Wolters Kluwer - Medknow