Indian Journal of Plastic Surgery
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Year : 2012  |  Volume : 45  |  Issue : 2  |  Page : 255--260

Chronic lower limb wounds evoke systemic response of the lymphatic (immune) system

1 Department of Surgical Research, Medical Research Center, Polish Academy of Sciences; Central Clinical Hospital, Warsaw Medical University, Warsaw, Poland
2 Department of Plastic Surgery, Benaras Hindu University, Institute of Medical Sciences, Varanasi, India
3 Department of Surgical Research, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
4 Department of Microbiology, Warsaw Medical University, Warsaw, Poland

Correspondence Address:
W L Olszewski
Department of Surgical Research, Medical Research Center, Polish Academy of Sciences, Warsaw
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0970-0358.101289

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Wound healing should not be considered as a process limited only to the damaged tissues. It is always accompanied by an intensive local immune response and in advanced stages, the systemic lymphatic (immune) structure. In this review we present evidence from our own studies as well as pertinent literature on the role of skin and subcutaneous tissue lymphatics at the wound site and of transport of antigens along with collecting afferent lymphatics to the lymph nodes. We also speculate the role of lymph nodes in raising cohorts of bacterial and own tissue antigen-specific lymphocytes and their participation in healing and not infrequently evoking uncontrolled chronic immune reaction causing a delay of healing. It is also speculated as to why there is a rapid response of lymph node cells to microbial antigens and tolerance to damaged-tissue-derived antigens occurs


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